IL42333A - Pyridyl derivatives of 1-phenoxy-3-amino-propane-2-ol,their production and pharmaceutical compositions containing them - Google Patents
Pyridyl derivatives of 1-phenoxy-3-amino-propane-2-ol,their production and pharmaceutical compositions containing themInfo
- Publication number
- IL42333A IL42333A IL42333A IL4233373A IL42333A IL 42333 A IL42333 A IL 42333A IL 42333 A IL42333 A IL 42333A IL 4233373 A IL4233373 A IL 4233373A IL 42333 A IL42333 A IL 42333A
- Authority
- IL
- Israel
- Prior art keywords
- phenoxy
- general formula
- propane
- stands
- substituted
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract 7
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004076 pyridyl group Chemical group 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 13
- 125000000217 alkyl group Chemical group 0.000 claims abstract 9
- 239000002253 acid Substances 0.000 claims abstract 7
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims abstract 7
- 238000000034 method Methods 0.000 claims abstract 7
- 150000003839 salts Chemical class 0.000 claims abstract 7
- 229910052736 halogen Inorganic materials 0.000 claims abstract 5
- 150000002367 halogens Chemical class 0.000 claims abstract 5
- 239000007859 condensation product Substances 0.000 claims abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000002252 acyl group Chemical group 0.000 claims abstract 3
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 3
- 125000003302 alkenyloxy group Chemical group 0.000 claims abstract 3
- 125000006193 alkinyl group Chemical group 0.000 claims abstract 3
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 3
- 125000000392 cycloalkenyl group Chemical group 0.000 claims abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- 238000007792 addition Methods 0.000 claims 6
- 150000002917 oxazolidines Chemical class 0.000 claims 6
- -1 alkinyloxy Chemical group 0.000 claims 4
- 238000009833 condensation Methods 0.000 claims 3
- 230000005494 condensation Effects 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 239000000047 product Substances 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- GUOGSANXPRRCMX-UHFFFAOYSA-N 1-(3-methoxyphenoxy)propan-2-ol Chemical compound COC1=CC=CC(OCC(C)O)=C1 GUOGSANXPRRCMX-UHFFFAOYSA-N 0.000 claims 1
- VRJJZESAMSRBTH-UHFFFAOYSA-N 1-(4-methoxyphenoxy)propan-2-ol Chemical compound COC1=CC=C(OCC(C)O)C=C1 VRJJZESAMSRBTH-UHFFFAOYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 208000001953 Hypotension Diseases 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 239000000150 Sympathomimetic Substances 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000005336 allyloxy group Chemical group 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229940124630 bronchodilator Drugs 0.000 claims 1
- 239000000168 bronchodilator agent Substances 0.000 claims 1
- 239000000496 cardiotonic agent Substances 0.000 claims 1
- 230000003177 cardiotonic effect Effects 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 230000036543 hypotension Effects 0.000 claims 1
- GCQRFUGXFJKEKG-UHFFFAOYSA-N n-[4-(2-hydroxypropoxy)phenyl]acetamide Chemical compound CC(O)COC1=CC=C(NC(C)=O)C=C1 GCQRFUGXFJKEKG-UHFFFAOYSA-N 0.000 claims 1
- 150000002989 phenols Chemical class 0.000 claims 1
- 229940125723 sedative agent Drugs 0.000 claims 1
- 239000000932 sedative agent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001975 sympathomimetic effect Effects 0.000 claims 1
- 229940124549 vasodilator Drugs 0.000 claims 1
- 239000003071 vasodilator agent Substances 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- JZEHWMUIAKALDN-UHFFFAOYSA-N 1-amino-3-phenoxypropan-2-ol Chemical class NCC(O)COC1=CC=CC=C1 JZEHWMUIAKALDN-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU65414 | 1972-05-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42333A0 IL42333A0 (en) | 1973-07-30 |
| IL42333A true IL42333A (en) | 1976-09-30 |
Family
ID=19727058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42333A IL42333A (en) | 1972-05-24 | 1973-05-22 | Pyridyl derivatives of 1-phenoxy-3-amino-propane-2-ol,their production and pharmaceutical compositions containing them |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US3940406A (en]) |
| JP (4) | JPS4941380A (en]) |
| AR (4) | AR199904A1 (en]) |
| AT (4) | AT326657B (en]) |
| BE (1) | BE800005A (en]) |
| BG (3) | BG20782A3 (en]) |
| CA (1) | CA1015357A (en]) |
| CH (4) | CH596180A5 (en]) |
| CS (4) | CS183692B2 (en]) |
| DD (1) | DD106835A5 (en]) |
| DE (1) | DE2323354A1 (en]) |
| ES (4) | ES415047A1 (en]) |
| FR (1) | FR2185411B1 (en]) |
| GB (1) | GB1409959A (en]) |
| HU (1) | HU165663B (en]) |
| IE (1) | IE37655B1 (en]) |
| IL (1) | IL42333A (en]) |
| LU (1) | LU65414A1 (en]) |
| NL (1) | NL7306691A (en]) |
| PH (3) | PH9827A (en]) |
| PL (1) | PL91588B1 (en]) |
| RO (2) | RO66268A (en]) |
| SE (1) | SE399425B (en]) |
| SU (4) | SU489309A3 (en]) |
| ZA (1) | ZA733513B (en]) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4066768A (en) * | 1973-12-27 | 1978-01-03 | Cassella Farbwerke Mainkur Aktiengesellschaft | Derivatives of 1-phenoxy-3-amino-propan-2-ol |
| US4088764A (en) * | 1973-12-27 | 1978-05-09 | Cassella Farbwerke Mainkur Aktiengesellschaft | Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-2-ol |
| US4139623A (en) * | 1974-05-14 | 1979-02-13 | C-G Corp. | Cyclic-substituted derivatives of 1-amino-2-propanol |
| CH592625A5 (en]) * | 1974-05-14 | 1977-10-31 | Ciba Geigy Ag | |
| JPS528043A (en) * | 1975-07-10 | 1977-01-21 | Toagosei Chem Ind Co Ltd | Adhesive |
| US4097490A (en) * | 1975-09-25 | 1978-06-27 | Merck & Co., Inc. | Pyroglutamic acid salts of t-butylamino-2,3-dihydroxypropane |
| US4060601A (en) * | 1976-06-15 | 1977-11-29 | Merck & Co., Inc. | Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines |
| JPH0774714B2 (ja) * | 1986-11-18 | 1995-08-09 | 中野冷機株式会社 | オープンショーケースの温度制御装置 |
| JP2858389B2 (ja) * | 1994-02-21 | 1999-02-17 | カシオ計算機株式会社 | 液晶表示装置およびその製造方法 |
| US5585388A (en) * | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
| US7244751B2 (en) * | 2003-02-14 | 2007-07-17 | Shenzhen Chipscreen Biosciences Ltd. | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1047927A (en) * | 1964-03-09 | 1966-11-09 | Ici Ltd | Alkanolamine derivatives |
| US3261829A (en) * | 1964-08-12 | 1966-07-19 | Searle & Co | Spiro(steroidal-6,3'-1-pyrazolines) and process |
| US3679693A (en) * | 1970-09-15 | 1972-07-25 | Smith Kline French Lab | N-pyridylalkyl-{62 -alkoxy-{62 -trifluoromethyl-phenalkylamines |
| CH578532A5 (en]) * | 1971-08-03 | 1976-08-13 | Cassella Farbwerke Mainkur Ag | |
| BE787057A (fr) * | 1971-08-03 | 1973-02-01 | Cassella Farbwerke Mainkur Ag | Derives du phenoxy-1 amino-3 propanol-2 et medicaments qui en contiennent |
-
1972
- 1972-05-24 LU LU65414A patent/LU65414A1/xx unknown
-
1973
- 1973-05-09 DE DE2323354A patent/DE2323354A1/de active Pending
- 1973-05-14 NL NL7306691A patent/NL7306691A/xx not_active Application Discontinuation
- 1973-05-16 HU HUCA346A patent/HU165663B/hu unknown
- 1973-05-21 SU SU1923622A patent/SU489309A3/ru active
- 1973-05-21 SU SU7301923620A patent/SU582755A3/ru active
- 1973-05-21 US US05/362,567 patent/US3940406A/en not_active Expired - Lifetime
- 1973-05-21 IE IE805/73A patent/IE37655B1/xx unknown
- 1973-05-21 SU SU1923621A patent/SU563120A3/ru active
- 1973-05-22 BG BG023691A patent/BG20782A3/xx unknown
- 1973-05-22 JP JP48056386A patent/JPS4941380A/ja active Pending
- 1973-05-22 BG BG024936A patent/BG21851A3/xx unknown
- 1973-05-22 JP JP48056387A patent/JPS4948675A/ja active Pending
- 1973-05-22 DD DD170987A patent/DD106835A5/xx unknown
- 1973-05-22 BG BG24934A patent/BG22072A3/xx unknown
- 1973-05-22 IL IL42333A patent/IL42333A/en unknown
- 1973-05-23 RO RO7300077378A patent/RO66268A/ro unknown
- 1973-05-23 CS CS7300003712A patent/CS183692B2/cs unknown
- 1973-05-23 CH CH737873A patent/CH596180A5/xx not_active IP Right Cessation
- 1973-05-23 AT AT450073A patent/AT326657B/de not_active IP Right Cessation
- 1973-05-23 ES ES415047A patent/ES415047A1/es not_active Expired
- 1973-05-23 CH CH737573A patent/CH581620A5/xx not_active IP Right Cessation
- 1973-05-23 GB GB2458273A patent/GB1409959A/en not_active Expired
- 1973-05-23 CH CH737673A patent/CH581621A5/xx not_active IP Right Cessation
- 1973-05-23 ES ES415045A patent/ES415045A1/es not_active Expired
- 1973-05-23 AT AT450273A patent/AT326659B/de not_active IP Right Cessation
- 1973-05-23 ZA ZA733513A patent/ZA733513B/xx unknown
- 1973-05-23 AR AR248189A patent/AR199904A1/es active
- 1973-05-23 CH CH737773A patent/CH581622A5/xx not_active IP Right Cessation
- 1973-05-23 CS CS7300003715A patent/CS183702B2/cs unknown
- 1973-05-23 AT AT450173A patent/AT326658B/de not_active IP Right Cessation
- 1973-05-23 AT AT450373A patent/AT326660B/de not_active IP Right Cessation
- 1973-05-23 RO RO7374886A patent/RO64607A/ro unknown
- 1973-05-23 AR AR248190A patent/AR199905A1/es active
- 1973-05-23 JP JP48056904A patent/JPS4948678A/ja active Pending
- 1973-05-23 SU SU1922038A patent/SU493958A3/ru active
- 1973-05-23 CS CS7300003714A patent/CS181241B2/cs unknown
- 1973-05-23 PH PH14648A patent/PH9827A/en unknown
- 1973-05-23 JP JP48056903A patent/JPS4948677A/ja active Pending
- 1973-05-23 ES ES415046A patent/ES415046A1/es not_active Expired
- 1973-05-23 AR AR248187A patent/AR199903A1/es active
- 1973-05-23 CS CS7300003713A patent/CS183701B2/cs unknown
- 1973-05-23 ES ES415044A patent/ES415044A1/es not_active Expired
- 1973-05-23 SE SE7307242A patent/SE399425B/xx unknown
- 1973-05-23 CA CA172,038A patent/CA1015357A/en not_active Expired
- 1973-05-23 PL PL1973162780A patent/PL91588B1/pl unknown
- 1973-05-24 FR FR7318866A patent/FR2185411B1/fr not_active Expired
- 1973-05-24 BE BE131502A patent/BE800005A/xx unknown
-
1974
- 1974-03-08 PH PH15602*UA patent/PH9369A/en unknown
- 1974-03-08 PH PH15601*A patent/PH9508A/en unknown
- 1974-05-23 AR AR248188A patent/AR200869A1/es active
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